[Obesity in humans is a matter of extreme discomfort and hence of commiseration. The following note ef observation on mice appearing in Nature will be of interest Editor.] It is well known that in mice, yellow is epistatic to other coat colours and that homozygous yellow mice do not occur owing to the lethal effect of the yellow gene in the homozygous condition. Dr. Danforth has recently shown (Jour. of Heredity, Vol. 18 No. 4) that healthy yellow mice always become abnormally fat on an ordinary diet, this tendency being even more marked in the females than in the males. Thus yellow females are often twice, and sometimes thrice, as heavy as others. The fat is partly sub-cutaneous and partly attached to the viscera. The evidence indicates that the obesity is produced by the same gene which produces the yellow coat pigmentation and not by a separate factor, since no cross-overs appear.
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